Nitric oxide for long haul CV, altitude sickness, hypertension and cardiovascular improve with Dr. Nathan Bryan

This week on The Less Stressed Life Podcast, I am joined by  Dr. Nathan Bryan . In this episode, we discuss episode topics: Nitric oxide for long haul CV, altitude sickness, hypertension and cardiovascular improve. 

KEY TAKEAWAYS:

• What is nitric oxide? 
• Why should people want to know about nitric oxide?
• What are some common lifestyle habits that disrupt nitric oxide production?
• What can someone do today to improve NO function?

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ABOUT GUEST:
Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry.

Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport, where he was the recipient of the Dean’s Award for Excellence in Research. Dr. Bryan has been involved in nitric oxide research for the past 20 years and has made many seminal discoveries in the field. Their lead drug candidate NOviricid is currently in phase 3 clinical trials for the treatment of COVID-19 in African Americans and Hispanics.

He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. Dr. Bryan has been involved in nitric oxide research for the past 20 years and has made many seminal discoveries in the field. His many seminal discoveries have resulted dozens of issued US and International patents and the product technology resulting from his discoveries and inventions has improved patient care worldwide. Dr. Bryan is a successful entrepreneur and Founder of HumanN, Inc, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC and Bryan Nitriceuticals, LLC. His product technology is responsible for hundreds of millions of product sales worldwide. Most recently, Dr. Bryan serves as Founder and CEO of Nitric Oxide Innovations, LLC, a privately-held, clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of nitric oxide based therapies. Their lead drug candidate NOviricid is currently in phase 3 clinical trials for the treatment of COVID19 in African Americans and Hispanics. Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry.

WHERE TO FIND:
Instagram:  @drnathansbryan
Website: www.drnathansbryan.com
Twitter:  @drnitric

WHERE TO FIND CHRISTA:

https://www.christabiegler.com/

On IG: instagram.com/anti.inflammatory.nutritionist/

Leave a review, submit a questions for the podcast or take one of my quizzes here: https://www.christabiegler.com/links

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TRANSCRIPT:

[00:00:00] Dr. Nathan Bryan: Nitric oxides a gas, and 99% of the products on the market are basically giving you precursors or substrates or amino acids and hoping that your body can convert it into nitric oxide. But the problem in people that are nitric oxide deficient is that they've lost the ability to convert those substrates to precursors.

[00:00:18] Dr. Nathan Bryan: Nitric 

[00:00:20] Christa: stress is the inflammation that robs us of life, energy, and happiness. Our typical solutions for gut health and hormone balance have let a lot of us down we're overmedicated and underserved at the less trust life. We are a community of health savvy women exploring solutions outside of our traditional Western medicine toolbox and training to raise the bar and change our.

[00:00:45] Christa: Each week, our hope is that you leave our sessions inspired to learn, grow, and share these stories to raise the bar in your life and home.[00:01:00]

[00:01:03] Christa: All right. Today on the Less Stress life I have Dr. Nathan Brian, who's an international leader in molecular medicine and nitric oxide biochemistry. Dr. Brian earned his undergraduate bachelor's degree in Biochem from the Neo University of Texas at Austin, and is doctoral degree from Louisiana State University School of Medicine in Shreveport, where he was recipient for the Dean's Award for Excellence in.

[00:01:25] Christa: He actually has like a 10 page bio, but I'm gonna summarize it to this. He's basically been involved in nitric oxide for the past 20 years and has had many seminal discoveries in the field. He is involved in development of products and drugs using nitric oxide, and his lead drug candidate called Noid is currently in phase three clinical trials for the treatment of Covid 19 in African Americans and Hispanics.

[00:01:50] Christa: So we'll talk all about nitric oxide today. Welcome, Dr. Brian. 

[00:01:54] Dr. Nathan Bryan: Kristin. It's great to be here with you. Thanks for 

[00:01:56] Christa: having me. Yeah. I love these nerdy topics. So does the audience, they [00:02:00] love like specific, really nerdy topics. So nitric oxide I feel has gotten a little bit of more of ma main stage presence as mouth taping became popular.

[00:02:10] Christa: But let's just back up to nitric oxide 1 0 1 and also before we even go there, How did this become your life's work? Or why? And it may be not that cool of a story, right? It may have just been like, this is what they had research dollars for , but how did this become, or is this an area you felt really passionate about?

[00:02:27] Christa: How did you end up in nitric oxide research? And then stay there for as long as 

[00:02:30] Dr. Nathan Bryan: you have? Yeah. Well, you know, Chris, it's like any career, right? It's a journey. And I think we, you know, we're, we're we encountered different things. Different parts of our life that allow us to pivot. But you know, for me, there was an early interest in science and medicine, even from high school, you know?

[00:02:44] Dr. Nathan Bryan: And so once I got a degree in biochemistry and really tested the job market out for a bachelor's degree in biochemistry, and it really wasn't, uh, all that many opportunities. So I, I realized I quickly had to go back in further my education and. So I knew I always wanted to do basic science [00:03:00] research. I loved the feeling of discovery.

[00:03:01] Dr. Nathan Bryan: I did undergraduate research at University of Texas, but I enrolled in lsu in a PhD program in cellular molecular physiology. Back, I guess it was 2000. And during that time, you know, we have to, you know, take all the courses and then we rotate through some research labs and one of. Slab I rotated through with a pharmacologist that had been in nitric oxide for probably about 15 years before that.

[00:03:25] Dr. Nathan Bryan: And so we knew it was important. A, a Nobel Prize was just awarded for the discovery of nitric oxide in 1998. And it was really intriguing to me, but it was this gas that was produced in the lining of the blood vessels, and it was gone in less than a second. Mm-hmm. . So there was still a lot of unanswered questions around nitric.

[00:03:41] Dr. Nathan Bryan: So like, you know, what goes wrong in people that can't make it? What are the clinical consequences? and then how do you detect and measure this molecule in humans or in patients and develop some type of prognostic or diagnostic molecular pattern on, you know, at-risk patients. Mm-hmm. . So that really piqued my interest.

[00:03:59] Dr. Nathan Bryan: And then, [00:04:00] you know, we started developing methods where we could detect nitric oxide at really low physiological concentrations. And then that really gave us the tools we. To really discover a lot of things that hadn't been discovered before. So, you know, during that time as a student, and I think I've published five or six papers, and then, you know, in my postdoc we were publishing 8, 10, 12 papers a year.

[00:04:19] Dr. Nathan Bryan: And then that's really how I got a name for myself, kind of a young up and coming guy in analytical chemistry and nitric oxide bio chemistry. and you know, we made a lot of discoveries and that's how I got into this field and that's how we'll continue. Yes. What I do today. We've learned a lot, but you know, there's still a lot we don't know.

[00:04:37] Christa: Right. Well, you brought up some of the questions that I have for sure, which is, but before we get into kind of how does our body make tric oxide, I mean, as we look at supplements and things, how to even stabilize this when it's gone in a second. But before we get there, why do we even care about nitric oxide?

[00:04:52] Christa: So tell us just a little bit of the 1 0 1. about? Why do people need to even know what it 

[00:04:57] Dr. Nathan Bryan: is? Well, it's a gas, it's a molecule [00:05:00] that's produced the lining of the blood vessels. That was the first pathway to be discovered, or the first cell type to be discovered. But now we know it's produced in the brain and the neurons.

[00:05:08] Dr. Nathan Bryan: It's how our immune system fights off invading pathogens from viruses and bacteria. So it's critically important in our immune dysfunction and I'm, I'm sure we'll go there. When we talk about our covid drug and how we recognize that nitric oxide deficiency was what was causing people that got covid, causing them to get sick and and die from covid.

[00:05:27] Dr. Nathan Bryan: So now it's recognized that the loss of nitric oxide production is the earliest event in the onset progression of most, if not all chronic. So we should care about it because you know, in America there are a lot of poorly managed diseases or medical conditions. And the reason for that is, is they don't get to the root cause.

[00:05:43] Dr. Nathan Bryan: And it's recognized now that the body cannot and will not heal without sufficient nitric oxide production. So there's two people we always talk to. There's the people who have been sick and and can't get better, and they're sick and tired of being sick and tired. And then they're the people who find nitric oxide and realize.

[00:05:59] Dr. Nathan Bryan: Now this [00:06:00] may be the missing piece of the puzzle that's preventing me from getting better. Mm-hmm. . So those people are looking for solutions to problems that they're living with and, and lived with for many years. Mm-hmm. or there's people, Krista, like you and I, who are typically healthy and don't wanna get sick, and we want to employ these strategies to allow our body to do as it's designed to do.

[00:06:18] Dr. Nathan Bryan: And that's heal and regenerate. So for us, nitric oxide is critically important as kinda a preventative for a prophylaxis for development of chronic disease. 

[00:06:26] Christa: Mm-hmm. , can you talk to me about how the body makes it in the body? What are the other co-factors or the pieces that have to be at play for the body to make nitric oxide?

[00:06:36] Christa: That's 

[00:06:36] Dr. Nathan Bryan: a very good question. So there's two ways the body makes nitric oxide in their completely independent production tablets. So in the early 1980s was discovered there's an enzyme that they called nitric oxide syntase. That's the enzyme that's found in neuron, that's found in our endothelial cells, which are the cells that line all blood vessels throughout the body.

[00:06:53] Dr. Nathan Bryan: And it's also found in our immune cells. So this enzyme. Arginine, which is a semi essential [00:07:00] amino acid into nitric oxide. But that's a very complex, complicated reaction. In fact, you need eight different co-factors and substrates to make that reaction work. And so if any of these are limiting or they become oxidized because.

[00:07:12] Dr. Nathan Bryan: The patient may be inflamed or under a lot of oxidative stress, then that enzyme becomes uncoupled and dysfunctional, so it no longer generates nitric oxide. Mm-hmm. . So some of those co-factors are tetra hytrin or BH four. You need fla independent co-factors. You need oxygen, you need glutathione, you need he iron, calcium.

[00:07:31] Dr. Nathan Bryan: So if any of those are limiting, this enzyme shuts down and you can't make it. Mm-hmm. . So that's the primary, and we call that endothelial dysfunction. And that enzyme becomes less functional with age. So there's this age-related decline in nitric oxide production that is due to the insufficient production by that NOS enzyme.

[00:07:49] Dr. Nathan Bryan: Mm-hmm. , I could see lots 

[00:07:50] Christa: of issues with the co-factors there. Not having enough of those. There's a lot of, there's, there's a lot of building blocks to make those, and then if you don't have those, you couldn't make nitric oxide. So that [00:08:00] would, I can understand where that would be an issue and the second.

[00:08:02] Christa: Yep. And 

[00:08:02] Dr. Nathan Bryan: so, you know, fortunately we know how to recouple that and, and replenish those cofactors. But the second pathway is through our. And this explains the mechanism of, you know, the Japanese diet of vegetarian, plant-based diet, the dietary approaches to stop hypertension because certain selections of food, primarily green leafy vegetables, have a higher concentration of a mineral called nitrate, and then the body converts when we consume nitrate through our diet.

[00:08:30] Dr. Nathan Bryan: By the activity of the bacteria that live in and on our body, they metabolize nitrate into nitride and nitric oxide. So this pathway is dependent upon three things. Number one, that we get enough nitrate from our diet. Number two, that we have the right oral bacterium, the nitrate reducing bacteria that are responsible for metabolizing this molecule.

[00:08:51] Dr. Nathan Bryan: And then third, we have to have sufficient stomach acid production in order for this pathway. Oh, 

[00:08:55] Christa: well there's still more yet more issues, . That's right. There's, [00:09:00] yeah, so there's a lot of, these are a lot of building blocks to go down . 

[00:09:03] Dr. Nathan Bryan: Yeah. There's a lot of things that get in the way of nitric oxide production.

[00:09:06] Dr. Nathan Bryan: And you know, when we revealed probably 10 or 15 years ago that the use of mouthwash disrupts the oral microbiome and prevents nitric oxide production causing and. Elevation and blood pressure and causing loss of the cardioprotective benefits of exercise. You know, there's 200 million Americans that wake up every morning and use mouthful.

[00:09:23] Dr. Nathan Bryan: Mm. And I think they do it with good intentions, but people don't understand there's collateral damage to these things. Just like we don't take an antibiotic every day for the rest of our life. Cause of the known medical problems that result from chronic antibiotic use from, you know, why would we use a mouthwash to disrupt the oral microbiome every day?

[00:09:42] Dr. Nathan Bryan: Mm-hmm. , but yet people do. Mm-hmm. . 

[00:09:44] Christa: So this one. . We need nitrates from green leafy vegetables. The body's gonna metabolize that into nitrate and the nitric oxide. We need the proper oral bacteria. We need stomach acid. You said one more thing I think for this one to, to 

[00:09:57] Dr. Nathan Bryan: work, right? Well, there's three. We have to get enough [00:10:00] nitrate in the diet and you know, the standard American diet is really depleted in nitrate.

[00:10:04] Dr. Nathan Bryan: So we're not getting enough from the standard American diet. We have to have the presence of the bacterium. So that's two. And then the third is stomach. . And that's really a problem because you know, there's 200 million prescriptions written for septics, Orix for antiacid, specifically proton pump inhibitors, and that shuts down nitric subduction.

[00:10:25] Dr. Nathan Bryan: Mm-hmm. from both that. So now there's clear evidence that people who have found these pdis, these xs for three to five. Have about a 35 to 40% higher incidence of heart attack. 

[00:10:41] Christa: So let's talk about how we measure nitric oxide in the body, because you've now peaked our interest that, oh, it's really important to immune dysfunction.

[00:10:49] Christa: And then we've talked about how it's created and all the issues for it. So how do people know that they have enough nitric oxide? Did you come up with ways that you can measure it in the. You 

[00:10:58] Dr. Nathan Bryan: know, that's been a challenge for [00:11:00] 20 or 30 years is how do you clinically measure nitric oxide deficiency? And because it's a gas, it's gone on less than a second.

[00:11:05] Dr. Nathan Bryan: It's not something we can measure like cholesterol or vitamin D or triglycerides in our blood. So we rely on really symptoms. But, you know, I developed a, a salivary test strip, I guess maybe 10 or 15 years ago. Because people just like the question you ask is how do you know? And so the only way to measure that was we've created the only point of care non-invasive diagnostic in the form of a salivary test strip.

[00:11:29] Dr. Nathan Bryan: So you can just apply some saliva to the end of this test strip, and if it turns bright pink, then that tells us that your body's able to. Generate nitric oxide or inorganic nitride through this Ontario salivary surgery. So, but it's, you know, I tell people it's a good tool to have in your toolbox, but it shouldn't be the only tool you use.

[00:11:45] Dr. Nathan Bryan: So we really rely on simple. Mm-hmm. . So how do you know if you're nitric oxide deficient? Yep. If you have an elevation in blood pressure, your body's not making nitric oxide. If you have insulin resistant diabetes, your body's not making nitric. If you get winded and [00:12:00] out of breath walking up a flight of steps, then your body's not making nioxin.

[00:12:04] Dr. Nathan Bryan: If you can't remember where you left your keys and you're developing forgetfulness and mild cognitive disorders, then your body's not making nioxin. If you have erectile dysfunction as a man or a woman, Then your body's not making nitric oxide to dilate the blood vessels of the sex organ to getting engorgement.

[00:12:20] Dr. Nathan Bryan: So all of those are kind of the primary signs and symptoms of nitric oxide deficiency. And the test strip is kind of a good way to validate that or verify. . Mm-hmm. . 

[00:12:29] Christa: Well, those were more severe symptoms, but if you're a healthy person, fatigue would be one. Right. Is there any other ones that are less severe that we could maybe look to for, Hey, maybe I could increase, and I also wanna talk about not only symptoms for maybe a more healthy person, but we talked about these other two pathways, and then I wanna talk a little bit about mouth taping and how that increases nitric oxide, if you have feelings about that.

[00:12:53] Christa: Yeah, no, there's, there's many ways 

[00:12:55] Dr. Nathan Bryan: the body makes nitric oxide. If you develop chronic fatigue, which [00:13:00] is a mitochondrial dysfunction, right? Mm-hmm. means the mitochondria aren't making sufficient energy to to power the cell. Mm-hmm. nitric oxide is what controls and regulates mitochondrial ATP production.

[00:13:10] Dr. Nathan Bryan: So again, if you develop chronic fatigue or you're just tired, lethargic all the time, then typically that's a sign of micro oxide deficiency neuropathy, where you have, you know, tingling or loss of sensation or sensory or motor function. The periphery in the arms of the legs, then that's a sign of nitric oxide deficiency because those small sensory nerves or motor neurons have to have a blood supply.

[00:13:31] Dr. Nathan Bryan: And when they're not getting sufficient blood supply, then they lose their function and you develop neuropathy. Mm-hmm. . So those are kind of the milder symptoms. Um, but yeah, when you talk about. You know, how do we increase nitric oxide production? Well, it's, it's a very complex science, but it's really a very simple strategy.

[00:13:49] Dr. Nathan Bryan: So it's, it's diet and lifestyle. It's moderate physical exercise. It's deep breathing, so nasal breathing or mouth taping. And so the same enzyme that's found in the lining of the blood vessels is [00:14:00] also found in our epithelial sills. That line all the, the sinus airways, the airways of the sinus, and when we breathe through the nose, They're MENA receptors on those cells that tell that cell to make nitric oxide.

[00:14:12] Dr. Nathan Bryan: So when we breathe through our nose, we're signaling the body to make nitric oxide, and we then we deliver that nitric oxide to the pulmonary ture. We dilate the bronchials, we dilate the pulmonary arteries, and we improve oxygen uptake and we improve oxygen delivery to every cell on the body. But the mouth breath.

[00:14:29] Dr. Nathan Bryan: You know, you're bypassing that pathway so you're not stimulating nitric oxide production. But here's the problem, Krista. In people with endothelial dysfunction, they also have epithelial dysfunction, meaning that enzyme nitric oxide sy isn't working in the lining of the blood vessel, then it's not working in the sinuses, in the epithelial the sinuses.

[00:14:49] Dr. Nathan Bryan: So you can tape your mouth and do nasal breath. all day till the cows come home. But until you correct the function of that enzyme, you're not gonna generate nitric oxide. Hmm. Yeah. [00:15:00] Well, 

[00:15:00] Christa: let's talk about, can you overdo nitric oxide? So, and this would be from an exogenous, probably the question before this is can you take exogenous nitric oxide?

[00:15:11] Christa: I mean, there, there are supplements out there, but how do you make this stable? Yeah. 

[00:15:15] Dr. Nathan Bryan: And that's been the confusion around consumers by these companies, marketing nitric ox. Products now for probably more than 30 years. You know, since 1998, there's been a number of companies that have hit the market with nitric oxide products, but the challenge has always been nitric oxides, A gas, and 99% of the products on the market are basically giving you precursors or substrates or amino acids and hoping that your body can convert it in the nitric.

[00:15:40] Dr. Nathan Bryan: But the problem in people that are nitric oxide deficient is that they've lost the ability to convert those substrates to precursors into nitric oxide. So most of those products, I mean, the analogy I always use is it's like putting gas in a car with a blown up engine. These people aren't out of fuel.

[00:15:55] Dr. Nathan Bryan: They're not out of substrates or precursors, or they're not deficient, arginine or [00:16:00] citraline. They've just lost the ability to convert those into nitric oxide. So those products don't do. Arginine, citraline based products don't do anything. Your body makes enough of those amino acids to saturate the enzyme.

[00:16:12] Dr. Nathan Bryan: So what we've done is completely different. Our whole concept when we were developing this in the research lab was, number one, if your body can't make nitric oxide, then we have to do it for you. We have to generate nitric oxide gs, and that's really been my claim to fame is I was the first person to develop a solid dose form of a bioactive.

[00:16:31] Dr. Nathan Bryan: So we have to do this in the form of a lozenge and this matrix that falls apart when you put in your mouth. And then as this matrix falls apart, these active components come together and we generate nitric oxide gas, and that's really the only way you can deliver it besides in a nasal canula.

[00:16:46] Dr. Nathan Bryan: Delivering the gas directly into the patients is through. This lozenge, it has to be in lozenge form. It has to be in lozenge form. Yeah. You know, because you can't put it in the capsule, you can't put it in the tablets. Cause you know, depending on if you're, if that person [00:17:00] makes stomach acid or not, or if you don't have the right bacteria, then that product's not gonna work for you.

[00:17:05] Dr. Nathan Bryan: So what we do is we generate nitric oxide, whether you have the right oral bacteria or not, whether you have stomach acid production or not. So the beauty of that is, is this product technology works in every single person the exact same way, depending upon whatever their underlying condition is. And so the next question you ask was, how do you know if you're too much?

[00:17:22] Dr. Nathan Bryan: Well, they're only too causes. Two signs of toxicity for nitric oxide. One is low blood pressure, so if you take too much your, your blood pressure will drop to an unsafe level, or you develop what's called met hemoglobinemia and you'll develop cyanosis. So too much nitric oxide will oxidize. The iron and hemoglobin and, you know, reduce the oxygen carrying capacity of your blood and you'll get, you know, cyanosis blew it around the lips.

[00:17:47] Dr. Nathan Bryan: But that's, I mean, we've never seen that, and that's, you know, it's a, it's a serious medical condition, but you know, you would have to almost intentionally overdose on nitric oxide to get to that level. Yeah. How much 

[00:17:59] Christa: would you have to [00:18:00] take for that to happen, 

[00:18:01] Dr. Nathan Bryan: would you guess? Well, the LD 50, which is the lethal dose, that would cause death in 50%.

[00:18:07] Dr. Nathan Bryan: The people who take it. Obviously these are done in research. Animals, mice, you know, is tons. So probably, you know, in terms of our lozenges, if you took a hundred of our lozenges at one point, probably some bad things are gonna happen to you. Got it. Yeah. If you take a hundred Tylenol pills, you're gonna die too.

[00:18:23] Dr. Nathan Bryan: You know? So uhhuh, , the dose dictates the poison, right? Yeah. So, you know, we've never had an issue with anybody overdoing the lozenge because number one, we have to safety first. Do no. . Then number two, we have to generate a certain amount of nitric oxide that's biologically active, that elicit a physiological response, and that's exactly what we've achieved with our technology.

[00:18:42] Christa: So aside from overdose, which is very, would be very challenging to actually accomplish and you'd have to do it exogenously, there really is no other harm to creating. You're expanding blood vessels. So aside from low blood pressure, there's no other known [00:19:00] harms from increasing nitric oxide. That's 

[00:19:02] Dr. Nathan Bryan: right.

[00:19:03] Dr. Nathan Bryan: Well, you know, years ago, Christa, when probably in the early two thousands, you know, a lot of clinicians and researchers thought that septic shock in the end, organ failure from sepsis was due to an overproduction of nitric oxide production. Because when you get septic, you know, your immune system generates a lot of nitric oxide to try to kill the infection.

[00:19:24] Dr. Nathan Bryan: And the thought process was, well, that's leading to systemic vasodilation, loss of perfusion, pressure, and then end. Failure and death. So they actually designed some clinical trials to give a nitric oxide inhibitor in septic patients. Mm. And the results were catastrophic? Yeah. I mean, the people that inhibited them and the patients that got the no inhibitor actually did worse than those who got the placebo.

[00:19:47] Dr. Nathan Bryan: Mm-hmm. . So inhibiting nitric oxide production actually killed more people from sepsis than the. So that told us that really the nitric oxide being produced during sepsis is actually protected and not [00:20:00] causal for the hypoperfusion and indoor failure. Mm-hmm. . So that really kind of changed the landscape because now today there's no known clinical situation.

[00:20:09] Dr. Nathan Bryan: Overproduction of nitric oxide is causal for the pathology. Mm-hmm. , 

[00:20:13] Christa: well, I can't leave this one piece you were talking about. People are not converting into nitric oxide because they've got endothelium or epithelium issue. So are we saying that this is a mucosal issue or is that enzymatic dysfunction?

[00:20:28] Dr. Nathan Bryan: So there are a lot of things that contribute to that enzymatic dysfunction. You know, there's a limitation of co-factors. So if you don't have enough glutathione or tetra hydrobot becomes oxidized or calcium, and a lot of these other co-factors that we discussed earlier, if they're not delivering being delivered to these individual cells, then that enzyme can't do its job.

[00:20:47] Dr. Nathan Bryan: So then we have to. , you know, recouple, that enzyme. And so fortunately we know how to do that. Prevent the oxidation of terin, which is the rate limiting step in nitric oxide production. Mm-hmm. . And so all of that technology is found. [00:21:00] in our laws and we, we provide a certain redox potential that prevents BH four oxidation.

[00:21:05] Dr. Nathan Bryan: So the beauty of our technology is if your body can't make nitric oxide, we do it for you. But we also improve the body's ability to make nitric oxide on its own. And that's really unique to this particular technology because no other nitric oxide product on the market does that. They're simply just giving you, you know, substrates and co-factors that your body.

[00:21:25] Dr. Nathan Bryan: Convert with no regard to the activity of the the enzyme that needs to be 

[00:21:29] Christa: recovered. Are there specific enzyme SNPs that say, Hey, if you've got this, this gene, you're not gonna convert nitric ator? There's actually lots of them, aren't there? There are. 

[00:21:40] Dr. Nathan Bryan: There's several. So obviously if you have a a s snip or a single nucleotide polymorphism, The INO or iNOS gene, then obviously that protein or enzyme is not gonna be, uh, functional.

[00:21:51] Dr. Nathan Bryan: So that's the obvious one, the not so obvious one and the one. Really prevalent is some Mt H ffr, this methylate rhythm [00:22:00] reductase enzyme. So it's obviously involved in the methylation cycle and methylation pathway, but it's also the enzyme that reduces boffin, the tetra, and that's the rate limiting step in nitric oxide production.

[00:22:13] Dr. Nathan Bryan: So if you have an Mt H ffr, SNP, then, then you become nitric oxide deficient. And depending upon which studies you read, you know, sometimes that's as much as 45 to 55% of the US popul. Has either a heterozygous or homozygous s n and the Mt H FFR gene. Mm-hmm. . So that becomes really a problem. Those are the obvious one.

[00:22:32] Dr. Nathan Bryan: There are others, you know, all these biochemical reactions feed into one another. So there are things that are even further upstreamed than Mt h FFR that could contribute to nitric oxide deficiency. 

[00:22:43] Christa: Yeah, and I think about when, if the main issue is enzymatic dysfunction, I like to think about what are the things that are influencing the genes besides the genetics, but lifestyle, diet, all the things that you mentioned, which was, it's a very complex set of reactions, but you know, it's, it's basically like, [00:23:00] Good diet, good.

[00:23:01] Christa: Like a bit of exercise. And the other things I heard from you were good stomach acid, not using mouthwash every day, nasal breathing incident of mouth breathing, which is a whole conversation on its own almost with like potentially , the way our mouths have evolved possibly, or, or just stress and all those things.

[00:23:18] Christa: Leafy greens or we didn't talk about beats, right? Beats are the, are hailed for their. Nutrients that help make nitric oxide production. Correct me if I'm wrong, if there's some other like superf food, but that's always the one on the shelf that's like, Hey, drink beets, , 

[00:23:32] Dr. Nathan Bryan: they're helping nitric oxide. Well, that's, again, that comes back to some creative marketing by companies with very little science.

[00:23:38] Dr. Nathan Bryan: Mm. You know, I've tested probably, if not every beat product on the market, the majority of. and 95% of the bead products out there don't contain any nitric oxide activity. So, and, and you think about this cuz you have to conceptualize this from start to finish mm-hmm. . So number one, the soil that the beads are grown in have to have sufficient nitrogen for them to accumulate [00:24:00] nitrogen.

[00:24:00] Dr. Nathan Bryan: Mm-hmm. . And then when you take the raw beads and make a a bee powder out of it, you know, that goes through a really stringent desiccation process. A lot of heat, and it destroys the nutrient d. Of that vegetable. Mm-hmm. So most of these bead products on the market are just dead beets. The only thing they do is turn your pee and your poop pink and red and cause a lot of anxiety.

[00:24:21] Dr. Nathan Bryan: But they do nothing in regards to nitric oxide. Mm-hmm. 

[00:24:24] Christa: Well, I was thinking, I am curious, my brain is thinking, how do you measure for nitric oxide activity if it takes all these other reactions to make nitric, you'd need a body. Right? Wouldn't you need a body? 

[00:24:36] Dr. Nathan Bryan: That's right. Well, we can make it. Well, we can we measure these products and in terms, Supplements or products, we can quantify the amount of nitrate or nitride in a given product during a serving size and see if that's sufficient for the body to convert into any meaningful physiological.

[00:24:52] Dr. Nathan Bryan: Active nitric oxide gas. Mm-hmm. . And that's kind of our metric in terms of measuring these products. As I mentioned, 95% of the nitric [00:25:00] oxide products out there, whether they're beets or other supplements, uh, don't do anything. So you're just creating a lot of ex, I shouldn't say that. They have a lot of good ingredients in 'em that could provide some benefit, but they do nothing in regards to increasing or enhancing nitric oxide production.

[00:25:16] Christa: Mm-hmm. , like if you did a salivary nitric oxide strip, for example, before and after, if someone consumed a bunch, no change. That's right. All right, cool. I was thinking, uh, about nitric oxide a lot when I was climbing High Mountain ranges in the Andes recently. And do you think nitric oxide is that, is my thought process correct.

[00:25:38] Christa: Should I have been trying to boost my nitric oxide or improve my nitric oxide production to improve my resilience in higher altitudes? 

[00:25:46] Dr. Nathan Bryan: Absolutely. Without a. We published on this, I think in 2007, and we were interested in the adaptive effects of people that live in Tibet. Cause if, if you live in Tibet, that's 12,000 feet above seed level, you know?

[00:25:58] Dr. Nathan Bryan: So if you and I were to go [00:26:00] to Tibet, fly to Tibet, you know, it would take us three to four days to acclimate. and we acclimate by producing more nitric oxide. So in our 2007 paper, we've discovered that the natives of Tibet are able to live at high altitude, which by the way, that's the partial pressure of oxygen is much less.

[00:26:18] Dr. Nathan Bryan: So you're breathing in less oxygen per breath. So they've adapted to that lower oxygen tension by improving and upregulating their nitric oxide output. Mm-hmm. . So even though they're breathing in less oxygen, they're delivering more oxygen per unit. Because they're making about 50 to a hundred times more nitric oxide than we do at sea level.

[00:26:38] Dr. Nathan Bryan: And in fact, that's the whole basis for people training at altitude. So we, you know, we send people and we've, we've done this in studies. Take people in Houston, send 'em up to Denver or Mexico City, which is 5,000 feet above sea level. And if they spend three to four days there, then you see about a 40 to 50%, sometimes a hundred percent increase in their nitric oxide production.

[00:26:57] Dr. Nathan Bryan: And then when they come back down to sea level, they're like a well [00:27:00] old machine. So this is the adaptive effects of healthy people. Now, you take a 50 year old, diabetic, overweight, hypertensive person to altitude, they're not gonna do well at all because they can't adapt because their body cannot make nitric oxide.

[00:27:15] Dr. Nathan Bryan: These are the people that get acute mountain sickness, high altitude pulmonary edema, and these are the people that can die from going down to two. So our whole strategy and our philosophy, again, if your body can't make nitric oxide cause you can't adapt to a low oxygen environment, then you've gotta take our nitric oxide and then we adapt for you.

[00:27:34] Dr. Nathan Bryan: Mm-hmm to bow your body to better deal with these lower oxygen tensions. Yeah. I 

[00:27:39] Christa: wish that a nitric oxide stuff was, I wish this was more commonplace discussed when you're talking about like altitude sickness and, and adjusting. But it makes sense that it's not because it's not incredibly me. Right. And we have kind of, it's kind of, um, it's debated [00:28:00] how people would increase it, right?

[00:28:01] Christa: Because if there's all these products on the market and not that many work that beautifully, then I can see why it's not a common recommendation. I can understand where that maybe would be an issue. I think Kristen, 

[00:28:12] Dr. Nathan Bryan: that's why what you do is so important and, and giving this information out to listeners.

[00:28:16] Dr. Nathan Bryan: So it's one thing we have to properly educate and. not just consumers, but physicians and healthcare practitioners. But the challenge with that is that there's companies out there, you know, and some of these companies I've been very close to that you know, are doing deceptive marketing and almost fraudulent marketing.

[00:28:33] Dr. Nathan Bryan: Cause they're positioning a product as a nitric oxide product when it does not generate nitric oxide. Mm-hmm. . So we have to hold these companies accountable because they're confusing consumers and especially. If people are going to altitude or taking these products for the management of blood pressure, and they take this in good faith that it's gonna generate nitric oxide as the label says it is, and then it doesn't.

[00:28:56] Dr. Nathan Bryan: It's just, not only is it disingenuous, but it's potentially very [00:29:00] dangerous. Is 

[00:29:01] Christa: nitric oxide ever given in a hospital setting to improve someone for blood pressure shoes or anything like that? Right. Because it's normally delivered as a gas. So that would be the main place where, no, 

[00:29:12] Dr. Nathan Bryan: that's right. The, the first FDA-approved indication for nitric oxide therapy was innovative nitric oxide for premature babies born with pulmonary hypertension.

[00:29:22] Dr. Nathan Bryan: Hmm. So they, when when babies are born premature, one of the last organs to fully. Is the lungs. And so premature babies have underdeveloped lungs. They, they don't get good oxygen exchange until they develop pulmonary hypertension. So now, you know, 20, 30 years later, this therapy has saved hundreds of probably millions of babies' lives.

[00:29:41] Dr. Nathan Bryan: Mm-hmm. And now, now they're using it off-label for adults undergoing cardiopulmonary bypass surgery. They used, there were a number of published clinical trials during covid, you know, really sick, uh, hypoxic covid patients in the I C U were given inhaled nitric oxide, and they got better. You improved blood [00:30:00] oxygen saturation.

[00:30:01] Dr. Nathan Bryan: You dilate the pulmonary circulation and overcome what's called hypoxic pulmonary vasoconstriction. 

[00:30:07] Christa: Yeah, I wonder why wasn't that more of a duh, right? Like, why wasn't that an automatic, Hey, we have this natural thing our body makes and it's antimicrobial. and it dilates this and is really useful in this indication.

[00:30:20] Christa: Why is that Not the automatic? So don't ask 

[00:30:22] Dr. Nathan Bryan: me. Well, because it worked and it because it wasn't a vaccine. Mm-hmm. . That's the not enough money. Not 

[00:30:27] Christa: enough money tied to this. Not enough money, . That's right. Follow that. So you just mentioned the profile of an overweight, hypertensive, pulmonary edema person.

[00:30:36] Christa: Let's talk about what happens when you give exogenous nitric oxide to that person and also, This Covid trial, right? Because the people that this is gonna help, I mean, I wanna talk about, we were just mentioning during, but really it's the post covid people that, that you're after, you know, hindsight 2020, where they're not really feeling good.

[00:30:55] Christa: So what happens when you give exogenous an tric oxide, this profile that really needs it? And then [00:31:00] also in long haul, covid. 

[00:31:01] Dr. Nathan Bryan: Well, you know, and everybody's different. And so when we look at responses, kinda a general response, everybody's different. So when I take this lozenge, I don't notice any different, I don't feel any different.

[00:31:11] Dr. Nathan Bryan: But if you take somebody who's a really sick person with a history of trans and ischemic attacks, it's hypertensive. You know, when they put that lozenger in their mouth, within seconds, they'll tell you. That they feel a difference. In fact, if we use an ultrasound and, and just measure the the carotid artery, within about 30 seconds of that lozenge, we can actually watch the carotid artery dilate.

[00:31:31] Dr. Nathan Bryan: Well, that's just one vascular bit, but it's happening throughout the body. So not only is it a vasodilator that dilates the blood vessels and improves. Oxygen delivery and blood oxygen saturation, but it prevents vascular inflammation. And that was kind of our segue into covid because we recognized in March of 2020 that the people that were getting covid and dying from Covid were the people who couldn't make nitric oxide.

[00:31:55] Dr. Nathan Bryan: Those were the elderly, primarily African Americans were the with high blood pressure, [00:32:00] diabetes, obesity, a previous heart attack. Those are the people who can't make nitric oxide. So when they got exposed to covid, what nitric oxide typically, Is, you know, for instance, I use me as an example cause I'm probably the best example out there.

[00:32:13] Dr. Nathan Bryan: When we're exposed to Covid or the flu or any respiratory virus, our body recognizes that. And then we mobilize our immune system and we do that through opening up blood vessels, through nitric oxide. We go to the side of attachment and, and respiratory viruses like covid. It's usually the airway epithelium.

[00:32:30] Dr. Nathan Bryan: And then our immune system generates a lot of nitric oxide over a short period of time. And that nitric oxide prevents the virus from. . But if you can't make nitric oxide, then that virus replicates propagates throughout the body. You get the spike protein that causes vascular inflammation. Platelets start sticking together and clotting and monocytes and neutrophils stick to the lining of the blood vessel and you get, you know, kidney disease and liver disease and pulmonary disease cause there's not enough blood flow getting through those [00:33:00] vessels now.

[00:33:00] Dr. Nathan Bryan: And then you get small micro clots that are. Strokes and heart attacks and you know, that all leads, that all points to a lack of nitric oxide production. Mm-hmm. So that was our argument when we thought our investigative new drug application to the FDA was, okay, if these people are deficient, nitric oxide, which basically explains.

[00:33:19] Dr. Nathan Bryan: Every single etiology of covid infection from the, those susceptible to infection, to binding to the ace receptor, to the systemic inflammation and, and systemic disease that lasted long after the active infection, all could be remediated by giving nitric. And that's exactly what we've seen in our drug trial.

[00:33:37] Dr. Nathan Bryan: We've now dosed over 650 patients with an nitric oxide, uh, drug. It's a double blind placebo controlled study, but even after a hundred patients, we already saw a statistically significant difference. Those between the two groups, the active and the placebo. How so? The science, well, you know, our primary endpoints were hospitalization, admission to the I C U and death.

[00:33:58] Dr. Nathan Bryan: Hmm. But we also [00:34:00] measured their symptomology so clearly in one group, and of course it's double blinded, it's we're blinded to this. The people in one group, if they got sick, their onset of symptoms, uh, the symptomology meaning that the time of the symptoms was completely abrogated in one group. And so at that point, you know, COVID was a very, uh, predictable timeline.

[00:34:24] Dr. Nathan Bryan: If you got exposed to Covid, three days later, you developed symptoms. And those symptoms, if you get really sick, would last for seven 10. He'd go to the ICU that put you on a mechanical vent, three days later you typically die. But in one group we found that if they got symptoms, they were very mild symptom.

[00:34:42] Dr. Nathan Bryan: And then the other group obviously had the normal course of disease. 

[00:34:46] Christa: So let's talk about. What you do, you stabilize nitric oxide and you've got these mini patents. I mean, again, correct me, the bio was long. I think you have many patents on different things. Right? And you're, you've, you have a, [00:35:00] essentially a drug that you're trying to produce.

[00:35:02] Christa: I actually interviewed a researcher recently and he was producing essentially the raw material for other people to put into products. I think the question is really, when I talk to him, I had to look for a particular ingredient in a product for it to be that particular raw material. In your case, it's not really an option because it has to be delivered in a very specific way.

[00:35:23] Christa: So you have, you really have to have control of everything from start to finish. 

[00:35:27] Dr. Nathan Bryan: Probably. That's right. Now we've produced and delivered, finished products, so, and you know, we've got only a handful of manufacturers who can do this, but obviously we have to source the raw ingredient. We have to make sure that we put this in a, in together a form that, you know, keeps these active materials separated until this matrix falls apart in the mouth, in the form of a laws.

[00:35:48] Dr. Nathan Bryan: Then we generate the gas. So everything we do and every product that me or my companies bring to market generates nitric oxide gas. We can quantify it, we can verify it, and if it doesn't, we don't bring it to market. So [00:36:00] you never have to guess if a Nathan, Brian product generates ni peroxide, if it has my name on it.

[00:36:05] Dr. Nathan Bryan: You can guarantee that it does, and we've got the method. To verify it and quantify it. You know, obviously we're going through FDA clinical trials, so these drugs aren't approved yet and all aren't, aren't on the market. So the drug company's called Nitric Oxide Innovations. We've got four or five drugs going into clinical trials now for covid 19 ischemic heart disease, got an Alzheimer's drug.

[00:36:26] Dr. Nathan Bryan: We've got a topical technology for diabetic ulcers and decubitus ulcers, pressure. It's really remarkable. It'll, it'll change the whole landscape of, of wound care. But as those drugs are going through the clinical trials we've brought to market some over-the-counter dietary supplements, and even in our own skincare line.

[00:36:44] Dr. Nathan Bryan: So our nutritional and diet and dietary supplement products are through a company called Brian Nitros, and that can be found at N oh two u.com. That's n o the number two, the letter U dot. Then we developed a skincare because once we knew how to make [00:37:00] nitric oxide, then the question was, what else can we do with this?

[00:37:03] Dr. Nathan Bryan: And the skin is an organ, just like the heart or the sex organs. And without sufficient blood supply, then that organ fails. And so fine line, fine lines and wrinkles appear. You know, you get dermatitis, you lose collagen, you lose hydration, and you look old. So in this dual chamber nitric oxide serum, I. You apply this to the skin, one pump from each chamber, and it generates nitric oxide gas right there on the surface of the skin.

[00:37:26] Dr. Nathan Bryan: And in fact, you can actually watch this product working before your eyes. Cause when you apply it to your skin, your skin will turn a light pink, and that's due to the opening up of the capillaries and increasing blood flow to the wherever you apply it. And this is a completely new category in skincare.

[00:37:41] Dr. Nathan Bryan: This is an unbelievable product. You know, most skincare and beauty products hide the blemishes, hide the fine lines and wrinkles. We get to the root of the problem in improved collagen deposition. We've got four published clinical trials, and this technology been an incredible product. It's called N 1 0 1.

[00:37:57] Dr. Nathan Bryan: Nitric oxide serum through a company called [00:38:00] pneuma Nitric Oxide. 

[00:38:01] Christa: Are we gonna get your before and afters of your skin, Dr. Brian ? 

[00:38:05] Dr. Nathan Bryan: That's right. Yeah. You know, it's like, it's proof principle that it works, but you know, it's one thing to work in individuals, but when you do, um, a randomized controlled clinical trial and look at a number of different patients before and afters, it's really transformative.

[00:38:21] Dr. Nathan Bryan: So I'm really proud of that product technology, and again, that's found at N dot. So 

[00:38:26] Christa: I have to ask this question and I could make up a bunch of answers, but I'd like to hear your answer. I mean, nitric oxide. Made in the body, right? You could, you've stabilized it, exogenously, it fits under the dietary supplement category technically, right?

[00:38:39] Christa: So you could just proceed and do supplements. So people buy this over the counter, but you're going drug route. Why are you going drug route? Is that to get into different types of audiences, essentially? Well, you 

[00:38:49] Dr. Nathan Bryan: know, I'm trained as a, a drug discovery, biochemistry. So you know, we get into academia and basic science.

[00:38:57] Dr. Nathan Bryan: To give physicians new tools to treat, [00:39:00] prevent, cure, diagnosed disease. That's really the basis of everything we did when I was in academia as a professor of medicine. So it was never my intent to develop a dietary supplement or nutritional product. , but the beauty of that kind of program and root is now it's readily accessible to people all over the world.

[00:39:18] Dr. Nathan Bryan: Right. You don't have to have a prescription to get this right. But as you know, it's the wild, wild west because any other company can say the exact same thing that I'm saying without any evidence in the, that's just basically the. , the dietary, the CHE Act, which basically allows dietary supplements to support basic structure function applications in the human body.

[00:39:39] Dr. Nathan Bryan: Mm-hmm. . So my objective now, and it hasn't changed since. 25 years in academia is to deliver safe and effective nitric oxide product technologies into every major market segment around the world. You know, we, we've been very successful with that in the nutrition dietary supplement space. You know, we've had it in the skincare and beauty for past two or three years.

[00:39:58] Dr. Nathan Bryan: But in order [00:40:00] for this to be mainstream and for everybody to know about it, just like taking niacin or NIS for lowering triglycerides, or, you know, prescribing a pill for, for hypertension. If we go through the rigor of doing FDA-approved clinical trials, you know, today if you go to your primary care physician asking about nitric oxide, most doctors out there are gonna look at you funny and don't know what you're talking about, right?

[00:40:23] Dr. Nathan Bryan: However, if we get a nitric oxide drug approved, then these physicians will learn about oxide. They'll know how important it's, and now they can prescribe you not only an effective drug for that in. But a drug without side effects. Yeah. And to me that's the most important thing about what we're doing.

[00:40:39] Dr. Nathan Bryan: Cause my research program. Designed around this concept of restorative physiology. Most drugs are pharmacology, right? They're inhibiting certain biochemical reactions, and when you do that, there's always consequences and they call those side effects. Mm-hmm. and I don't watch a whole lot of tv, but when I do watch TV and I see these drug commercials come on, they're [00:41:00] 32nd drug commercials, 25 seconds of that 30.

[00:41:03] Dr. Nathan Bryan: Commercial are side effects. Mm-hmm. , I mean, and I don't know why people would even want to take, if they listen carefully to the commercials, no one in their right mind would take these drugs or even ask their doctor about these. Mm-hmm. . So what we do is basically give what's missing. We give nitric oxide to the body doses that the body normally produces.

[00:41:21] Dr. Nathan Bryan: It's just so we're not inhibiting any reactions. We're not causing side effects. So this is a completely new paradigm in drug discovery. Yeah. And I think that's why it will change the face of healthcare and it will be the way we treat people for the next hundred years, how 

[00:41:33] Christa: many years until we see nitric oxide entering the drug space.

[00:41:37] Christa: I mean, you're the guy with the first 

[00:41:39] Dr. Nathan Bryan: row seat. Yeah, I think within the next 12 to 24 months, we'll start getting some of our drugs approved, because here's the deal, it's so remarkable and it's potency. We've been very fortunate and very diligent in trying to figure out, number one is it's safe, do no harm, but number two, provide a dose of nitric oxide that's not only safe, but it's efficacious in many different indications.

[00:41:58] Dr. Nathan Bryan: Mm-hmm. . So this [00:42:00] takes, you know, typically about 10 years and 800 million to get a drug to market. I think we've been able to fast practice not only cause of covid, but cause of our drug is so, , but now we're able to go into straight into phase three clinical trials for any oral formulation we go to.

[00:42:14] Dr. Nathan Bryan: Mm-hmm. so many of these, I think we can, we've gotten feedback from the fda, we know what to do. We have a clear regulatory path. We just have to do the study and let the drug perform. Mm-hmm. . So I think within the next 18 to 24 months, we'll have our nitric oxide drugs approved on the. and continue to change lives all around the world.

[00:42:32] Dr. Nathan Bryan: Cool. Well, I 

[00:42:33] Christa: hope, I wish you a lot of success. So the last question that people wanna make sure we get in always is, you know, we produce nitric oxide in our body, and we've covered this a little bit, but it's such a good place to kind of end before we get to where people should go find you online, which is what is something that you think, like if you were trying to just improve your nitric oxide production on your own today for free, what would 

[00:42:57] Dr. Nathan Bryan: you go.

[00:42:57] Dr. Nathan Bryan: Well, that's a very good question and a very common question. I tell [00:43:00] people, you have to do two things. Stop doing the things that disrupt it and start doing the things that promote it so we can kind of delve into those. So people have to stop using mouthwash. It's clear evidence now that if you use mouthwash, you disrupt the oral microbiome, dis decrease nitric oxide production, your blood pressure goes up.

[00:43:16] Dr. Nathan Bryan: You have to get rid of fluoride in your toothpaste, fluoride in your drinking water, fluorides and antiseptic. It's a neurotoxin and it kills your thyroid function. So by fluoride free toothpaste, get a home filtration system that removes fluoride and chlorine from your drinking water. Stop using antacids.

[00:43:32] Dr. Nathan Bryan: Your body cannot and will not heal without stomach acid in production cause shuts down nitric oxide production. then stop eating a lot of high carbohydrate meals because that the sugar in these diets stick to the enzyme that makes nitric oxide and makes it dysfunctional. So if you just do, stop doing those three things, number one, you're gonna save money.

[00:43:50] Dr. Nathan Bryan: Number two, your body's actually gonna thank you for it. And then, you know, just moderate physical exercise as as little as 20 minutes of moderate physical exercise a. [00:44:00] 2030 minutes of sunlight or infrared sauna, there's certain wavelengths of light that stimulate nitric oxide production, then throw in some more green leafy vegetables and when all else fails and the people don't wanna do that or can't do that, then we have product technology that does it for you.

[00:44:14] Christa: Mm-hmm. What's the wavelength for stimulating nitric 

[00:44:16] Dr. Nathan Bryan: oxide? Well, it occurs at both end of the spectrum. So ultraviolet light, we realized that will will cleave nitric oxide bound. Styles. So obviously there's a limit of penetration of UV light into the skin. And then the other end of the spectrum is the near and far infrared.

[00:44:34] Dr. Nathan Bryan: You know that frequency of light will actually not nitro oxide off of metals. So it'll re any nitric oxide, and we call these photo layal stores, but if you're nitric oxide deficient, obviously you have less of these photo layal stores. So the efficacy of light therapy is gonna be much reduced. So we like to tell people if you're gonna go out in the sun or sit in an infrared sauna or do light therapy, Titrate up your nitric oxide level before, take our nitric oxide supplement or go eat [00:45:00] some spinach or kale or arugula, or I would say beets, but most beets don't contain any nitrate.

[00:45:05] Dr. Nathan Bryan: Mm-hmm. , and then do the light therapy, and it makes everything else work better. 

[00:45:09] Christa: Cool. Where should people find you online? You know, I, for 

[00:45:12] Dr. Nathan Bryan: I send people to my educational website. It's dr nathan sbri.com. I'm not selling you anything on there. I'm just providing education. There's a six minute video. I do a monthly blog.

[00:45:22] Dr. Nathan Bryan: I'm on Instagram, Dr. Nathan s Brian, Twitter at Dr. Nitric. You know, I think social media, I'm not a big social media fan, but. You know, I think it's the way of the, the future and certainly the way most people get their information. So we have a, a pretty good presence on social media. You should be, so that's where I 

[00:45:39] Christa: send Dr.

[00:45:40] Christa: Nitric oxide on both platforms. That would be way cooler. Just 

[00:45:43] Dr. Nathan Bryan: so you know, Well, sometimes those handles are taken. Yeah, 

[00:45:47] Christa: true. Probably. All right, well, cool. I wish you the best of success with your drug trial so we can be recommending things without side effects that will help people. I hope that that is, goes seamlessly and you're [00:46:00] very successful.

[00:46:00] Christa: Thanks for coming 

[00:46:01] Dr. Nathan Bryan: on today. Thank you very much, Kristin. 

[00:46:04] Christa: Sharing and reviewing this podcast is the best way to help us succeed with our mission. To help integrate the best of East and West and empower you to raise the bar on your health story, just go to review this podcast.com/less stressed life.

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